Yamame. She's the reason I have over 200 attempts on Kisume's midboss card on one of the shottypes. Fucking opener. Final card sometimes gets me, but not as much as that.
Minoriko also gets a mention for how easy it is to die on some of her stuff.
Wriggle's fine as a boss, it's her midboss that fucks a run up, not the boss fight.