I'm not at loss for words, I can verbal diarrhea about Danganronpa forever. My theories are very, very rarely even correct!
Alright, so the way I see it the biggest question right now is, obviously, who the villain is. These are the possible culprits as I see it:
-A member of Future Foundation. This seems like the obvious one, since we don't know them and one of them could very easily be super shady. Right now my money is on
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-Someone from Ultra Despair Girls. Haiji and/or Monaca are the most obvious culprits. I feel like this is fairly unlikely since it wouldn't be that much of a twist.
-Some from Remnants of Despair. We don't know who's even active right now, but it could be any of them. Hajime or Nagito are very possible, especially Nagito if he's awake. Again, not likely to be terribly interesting so possibly not that likely.
-Byakuya. He's an asshat and I hate him, therefore he must be the culprit. He's not immediately present that I noticed so he might be pulling the strings from the background somewhere. I don't really believe he's THAT much of a dick, but it's not impossible.
-Alter Junko. She was the villain in Goodbye Despair already, but we have yet to get a great excuse for why she hasn't been copied onto a million hard drives and rendered immortal, so technically she's kind of the most likely. But as an interesting option she's the least likely because that would be super boring.
-Alter Ego. Despite having been beaten by Junko multiple times Alter Ego seems to still be alive and well, so it's not really clear if the AI characters can actually die. Alter Ego survived her encounter with Alter Junko despite being defeated, and it's not clear if she survived beyond that, but I feel like we don't really have a reason to assume she didn't. And if that's the case then it makes a lot of sense to me that the reason Alter Junko didn't erase her is because she corrupted her after taking over the Neo World Program. This is my outside chance bet following "someone from Future Foundation", but I admit it would be pretty far out of left field and also pretty repetitive.
-A fucking ghost. Guys, remember how FUCKING GHOSTS EXIST IN THIS FRANCHISE APPARENTLY? How could a ghost not have done it now that that's a thing?