Unless they are level 99 with 200+ eggs, I'd think not. Just consider that normal hera, one of, if not the easiest descend boss hits 12k a turn, every turn... I mean 1 turn cooldown attacks.. Even if you get dark resist leads, then you're left with the problem of killing hades in time which is really hard to do without a damage lead unless you have a luci nuke, some gravities, etc. Neptune can also be pretty 1shoty for certain teambuilds, and his defense all but requires a luci sub, poison sub, or defense negation sub if you don't have double spike damage leads. Also consider that while odin makes 12k hits small... even small hits are hard to heal when they happen EVERY TURN...so you really can't rely on odin to save you from them unless you have a ammy lead or something.
speaking of spike damage leads... I want to farm hera for skillups but she takes too long still... I want a spike damage team that can clear it consistently but I don't think my haku builds are quite up to snuff yet. Maybe if I had a 2nd ecchinida.
Also I find that the team suggestion things for many descend dungeons are ridiculous... ok so I've already said that, but even parties that seem relatively doable, you look at their hp requirement and..wut... For example, there was one dungeon which suggested a haku lead/team, TWO ecchinida's, something ELSE with crap for hp, and something with like 3.5k hp IF level 99... and it said hp of 19k.. HTF YOU HAVE 19K WITH 3 SUBS UNDER 1.2kHP!?!?!?!?! Seriously. I have level 80 haku, level 99 hera, level 80 siggy, level 60 ecchi, but early bloom so wtf, level 80 hades, level 99 team haku+180, and I only have 15k hp!
Do they expect your entire group to be full of level 99 +300? seriously.