MoF works fine without vsync.
Unfortunately, I don't have any previous versions of Wine, I typically uninstall old components after updating everything.
With DDC and ISC, I get those errors and then I presume Wine crashes or freezes. Terminal still lists Wine in the title during this but nothing ever happens no matter how long I wait. I just assume Wine encountered something it couldn't handle and freaked.
I don't use winetricks, just MacPorts with dev builds of wine.
Actually, I was about to post this when I went to test something. How are you running MoF and the others, windowed or fullscreen? I've been doing them fullscreen. I just tested MoF in windowed and it's locked to 29.7 fps and is experiencing slowdown (no vsync patch). Aaaaaand after doing that I went back to fullscreen and the fps is hanging around 50 but it's erratic. This looks more like a memory leak or something. I think I need to restart this system.
EDIT: Ok, I tested MoF again with windowed first, still locked to 30 fps, and then back on fullscreen and it went back to a normal 60. (still without vsync) I think what happened earlier was because the system was overheating, as everything on it suddenly became really slow to respond, so I let the machine cool down a bit. DDC and ISC still won't load up.