What if America decided to make a Touhou game?
Rena Hatel is the last member of a long bloodline of ancient warriors, specialized in the vanquishing of powerful demons known as Yoi'Ka. When she was a child her family was been slaughtered by a mysterious fox-themed sorcerer who goes by the name Raphael and his giant panther demon familiar Cherkhan. Rena is adopted by Sam Iban, a demon-turned-good who appears as a large, muscular afro american man with a pair of horns on his head, cool shades and a penchant for beer. He raises Rena and teaches how to deal with demons, reaching into her bloodline powers and supplies her with the best Yoi'Ka killing gear around. All grown up Rena sets out to find Raphael and take revenge for her family.
Using a powerful spear/sword hybrid called the Gohei, a Ball-and-Chain called the Hatel Orb and her own holy powers Rena faces thousands of Yoi'Ka, learning abilities, getting new weapons and even skimpier outfits along the way. Rena has no mercy for Yoi'Ka, especially the common Faruni type Yoi'Ka, who often end up being torn in half by Rena's sheer strength or with a sword driven through their throat and then forcefully pulled out from the other side. They're mindless leader Cirunos get's an even worse treatment by getting it's wings forcefuly torn of and stab into it's own chest. (As you can see, it's a combo of Devil May Cry, Bayonetta and God of War.)
In her gory battles Rena meets fellow demon hunters Marisa Kartel, a gun-toting witch with a huge attitude and a figure that would make Bayonetta jealous, Alfred, a slightly cowardly news reporter who follows Rena around to get a good scoop, but helps when truly needed, Sabin, a rival demon hunter from a bloodline similiar to that of Rena's, and Richard, a kind young man who asks Rena to collect various artifacts in exchange for money or weapons. There's also Patchington, an elderly gentleman with much knowledge of demon lore, who in fact has certain connections with a neutral vampiric Yoi'Ka.
After several brutal battles with mighty Yoi'Ka Lords Rena finaly faces Raphael, whose scheme is finally discovered: by sacrificing large amounts of both human and Yoi'Ka blood Raphael tries to summon the Evil God Yunk'Arin (who looks and sounds like the Elder God from Legacy of Kain, only way bigger, way more powerful and possessing even more eyes). This creator of Yoi'Ka kind will reshape all of existance into it's own twisted image. Raphael wishes to revive Yunk'Arin and make a world for only Yoi'Ka. Raphael tries to sacrifice Rena to make Yunk'Arin even more powerful, but Rena defeats him in a long, epic battle. Raphael is forced to sacrifice himself and Cherkhan to summon Yunk'Arin afterall, and thus condemns the world to an eternity of darkness. The unspeakable horror emerges and defeats Rana effortlessly. When all seems grim, all of Rena's friends reappear and start attacking Yunk'Arin. They're will to keep fighting for the world and their love for Rena manages to reawaken her, and allowing her to fully access the power of the Hatel bloodline.
One last epic battle commences between Rena and Yunk'Arin, which involves many overpowered abilities, explosions, transformations, quick-time events and psychedelic battle fields.
Yunk'Arin tries one last ditch attack by copying Rena's form and fight fire with fire, but in the end it get's vanquished by getting stabbed by several light swords, suffering many brutal kick and punch combos, getting blasted by everyone's ultimate attacks and getting shot square in the eye, resulting in a magnifecent over-the-top explosion.
In the end Rena pairs up with the character with whom she got the highest relationship score, may this either be Sabin, Marisa, Richard or Alfred. Rena however sets out when Yoi'Ka start to emerge once again, making way for several sequels.