Wow, Pyromaniac is very OP. When I played and had two defense flies, Little CHAD, and Pyromaniac, it happened to be my most defensive run yet. My power was at a low two, but I basically had unlimited HP (over 60 bombs). Well, beat Isaac with everyone (excluding The Lost) except Cain and Judas (the latter beating the boss rush however). I'm going to have to beat The Lamb eventually, however I'm getting everyone's Isaac and Chest items first.