Haven't seen Death Battle, but why the head scratching? I've seen Jojo's Bizarre Adventure, but never read the comics, so does Dio have any other hidden abilities or something?
It'd probably be nerfed for DB standards, but in the Jojoverse, Stand users can only be defeated by other Stands, due to Stands going so far as to physically protect their users, whether the user wishes it or not(For example, Kujo Jotaro takes a Police officer's gun, puts it to his head, and fires the bullet, which his stand catches. To note, it's pretty much right at his head). At the same time, their Stands can only be seen by other Stand Users. Since Sakuya doesn't have one, she wouldn't be able to see it
Again, it would probably be nerfed by Death Battle standards, so who knows.